Heart Disease (by DrJohnM)

Heart disease is serious.  It is the most common cause of death.

Heart disease is also our most preventable disease.

Heart disease is about inflammation.  The same mechanisms that cause the throat to swell from an infection, the skin to redden after an insect bite, and a scar to form after a cut are what cause heart problems.

Inflammation hurts the heart by two bad things: reducing its supply of nutrients and inducing changes in the heart muscle that could promote rhythm problems.

The heart, like any organ, requires a steady flow of blood from blood vessels. The coronary arteries lie on the outside of the heart. When drawn on paper coronary arteries look like inert pipes, but in reality the walls of these arteries, called the endothelium, are teaming with activity.  Endothelial cells grow, secrete chemical messengers, slough off and sometimes break.  Meanwhile, platelets, ‘the sticky’ cells in blood interact physically and chemically with these same highly active cells in the arterial wall.

In most forms of acquired heart disease, this interaction of blood and artery is where the rubber hits the road.  More inflammation means the endothelium is more apt to swell (with fatty deposits), more apt to redden (with blood clots) and more apt to scar.  This process is called hardening of the arteries or atherosclerosis.

Inflammation also activates platelets, making them stickier, and therefore more likely to clot and attach to the inflamed endothelium.  A blood clot that attaches to an inflamed blood vessel wall is the mechanism of acute events like heart attack and sudden death, and in the brain, strokes.

Heart health, therefore is about lowering inflammation.  The things that lower inflammation are well known.  Medical people call these Primary Prevention Strategies; regular people call it Healthy Living:

• Pick your parents well.  Obviously, we have no choice here. but since genetics plays a large role in susceptibility to heart disease, knowing your family history is a powerful tool.
• Do not smoke.  Smoking is highly inflammatory.
• Control blood pressure. Over time high blood pressure weakens the blood vessel wall.
• Control blood-sugar or avoiding diabetes altogether. Insulin is a growth factor which facilitates the deposition of fat and proliferation of scar tissue.  These are bad for arteries.
• Control cholesterol levels. Maintain low levels of “bad” (LDL) cholesterol and high levels “good” (HDL) cholesterol.
• Improve nutrition. Eat less. Eat better.
• Exercise smartly. Exercise is recommended every day that we eat.
• Sleep well.
• Be happy.  Anger and negative-thinking are also inflammatory.

At the core of preventing heart disease is ourselves. People can choose heart health.

Cardiologists are really good–and getting better all the time–at treating heart disease once it occurs.  We have effective medicines, innovative procedures and implantable devices all of which treat existing problems.  (Medical people call this Secondary Prevention; I sometimes call it the “fury of modern medicine.”

Currently, we (doctors and patients) are far less effective in using the much simpler and cost-effective treatment strategies above.

Technology makes our lives seem easier, but it can also make our lives more stressful, more complex, and more inflamed.  As society advances so does the milieu of heart disease.

Writing about cycling and heart disease go hand in hand.  I have grouped these under categories labeled healthy living, exercise, obesity, nutrition and of course, inflammation.

You may also find useful information under the archived list of posts labeled General Cardiology and General Medicine.